Heterosubtypic cross-reactivity of HA1 antibodies to influenza A, with emphasis on nonhuman subtypes (H5N1, H7N7, H9N2)
Identifieur interne : 000021 ( 1957/Analysis ); précédent : 000020; suivant : 000022Heterosubtypic cross-reactivity of HA1 antibodies to influenza A, with emphasis on nonhuman subtypes (H5N1, H7N7, H9N2)
Auteurs : Dennis E. Te Beest [Pays-Bas] ; Erwin De Bruin [Pays-Bas] ; Sandra Imholz [Pays-Bas] ; Marion Koopmans [Pays-Bas] ; Michiel Van Boven [Pays-Bas]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antiviraux (immunologie), Enfant, Enfant d'âge préscolaire, Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (virologie), Grippe humaine (anatomopathologie), Grippe humaine (virologie), Humains, Jeune adulte, Oiseaux, Réactions croisées, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (isolement et purification), Sous-type H7N7 du virus de la grippe A (immunologie), Sous-type H7N7 du virus de la grippe A (isolement et purification), Sous-type H9N2 du virus de la grippe A (immunologie), Sous-type H9N2 du virus de la grippe A (isolement et purification), Sujet âgé.
- MESH :
- anatomopathologie : Grippe chez les oiseaux, Grippe humaine.
- immunologie : Anticorps antiviraux, Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Sous-type H7N7 du virus de la grippe A, Sous-type H9N2 du virus de la grippe A.
- isolement et purification : Sous-type H5N1 du virus de la grippe A, Sous-type H7N7 du virus de la grippe A, Sous-type H9N2 du virus de la grippe A.
- virologie : Grippe chez les oiseaux, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Humains, Jeune adulte, Oiseaux, Réactions croisées, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies, Viral (immunology), Birds, Child, Child, Preschool, Cross Reactions, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (isolation & purification), Influenza A Virus, H7N7 Subtype (immunology), Influenza A Virus, H7N7 Subtype (isolation & purification), Influenza A Virus, H9N2 Subtype (immunology), Influenza A Virus, H9N2 Subtype (isolation & purification), Influenza in Birds (pathology), Influenza in Birds (virology), Influenza, Human (pathology), Influenza, Human (virology), Middle Aged, Young Adult.
- MESH :
- chemical , immunology : Antibodies, Viral.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N7 Subtype, Influenza A Virus, H9N2 Subtype.
- isolation & purification : Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N7 Subtype, Influenza A Virus, H9N2 Subtype.
- pathology : Influenza in Birds, Influenza, Human.
- virology : Influenza in Birds, Influenza, Human.
- Adolescent, Adult, Aged, Animals, Birds, Child, Child, Preschool, Cross Reactions, Humans, Middle Aged, Young Adult.
Abstract
Epidemics of influenza A vary greatly in size and age distribution of cases, and this variation is attributed to varying levels of pre-existing immunity. Recent studies have shown that antibody-mediated immune responses are more cross-reactive than previously believed, and shape patterns of humoral immunity to influenza A viruses over long periods. Here we quantify antibody responses to the hemagglutinin subunit 1 (HA1) across a range of subtypes using protein microarray analysis of cross-sectional serological surveys carried out in the Netherlands before and after the A/2009 (H1N1) pandemic. We find significant associations of responses, both within and between subtypes. Interestingly, substantial overall reactivity is observed to HA1 of avian H7N7 and H9N2 viruses. Seroprevalence of H7N7 correlates with antibody titers to A/1968 (H3N2), and is highest in persons born between 1954 and 1969. Seroprevalence of H9N2 is high across all ages, and correlates strongly with A/1957 (H2N2). This correlation is most pronounced in A/2009 (H1N1) infected persons born after 1968 who have never encountered A/1957 (H2N2)-like viruses. We conclude that heterosubtypic antibody cross-reactivity, both between human subtypes and between human and nonhuman subtypes, is common in the human population.
Url:
DOI: 10.1371/journal.pone.0181093
PubMed: 28715468
PubMed Central: 5513445
Affiliations:
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PMC:5513445Le document en format XML
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Te Beest</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, 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Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Boven, Michiel" sort="Van Boven, Michiel" uniqKey="Van Boven M" first="Michiel" last="Van Boven">Michiel Van Boven</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Antibodies, Viral (immunology)</term><term>Birds</term><term>Child</term><term>Child, Preschool</term><term>Cross Reactions</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (isolation & purification)</term><term>Influenza A Virus, H7N7 Subtype (immunology)</term><term>Influenza A Virus, H7N7 Subtype (isolation & purification)</term><term>Influenza A Virus, H9N2 Subtype (immunology)</term><term>Influenza A Virus, H9N2 Subtype (isolation & purification)</term><term>Influenza in Birds (pathology)</term><term>Influenza in Birds (virology)</term><term>Influenza, Human (pathology)</term><term>Influenza, Human (virology)</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe humaine (anatomopathologie)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Jeune adulte</term><term>Oiseaux</term><term>Réactions croisées</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (isolement et purification)</term><term>Sous-type H7N7 du virus de la grippe A (immunologie)</term><term>Sous-type H7N7 du virus de la grippe A (isolement et purification)</term><term>Sous-type H9N2 du virus de la grippe A (immunologie)</term><term>Sous-type H9N2 du virus de la grippe A (isolement et purification)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Sous-type H7N7 du virus de la grippe A</term><term>Sous-type H9N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H7N7 Subtype</term><term>Influenza A Virus, H9N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H7N7 Subtype</term><term>Influenza A Virus, H9N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term><term>Sous-type H7N7 du virus de la grippe A</term><term>Sous-type H9N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Birds</term><term>Child</term><term>Child, Preschool</term><term>Cross Reactions</term><term>Humans</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Jeune adulte</term><term>Oiseaux</term><term>Réactions croisées</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Epidemics of influenza A vary greatly in size and age distribution of cases, and this variation is attributed to varying levels of pre-existing immunity. Recent studies have shown that antibody-mediated immune responses are more cross-reactive than previously believed, and shape patterns of humoral immunity to influenza A viruses over long periods. Here we quantify antibody responses to the hemagglutinin subunit 1 (HA1) across a range of subtypes using protein microarray analysis of cross-sectional serological surveys carried out in the Netherlands before and after the A/2009 (H1N1) pandemic. We find significant associations of responses, both within and between subtypes. Interestingly, substantial overall reactivity is observed to HA1 of avian H7N7 and H9N2 viruses. Seroprevalence of H7N7 correlates with antibody titers to A/1968 (H3N2), and is highest in persons born between 1954 and 1969. Seroprevalence of H9N2 is high across all ages, and correlates strongly with A/1957 (H2N2). This correlation is most pronounced in A/2009 (H1N1) infected persons born after 1968 who have never encountered A/1957 (H2N2)-like viruses. We conclude that heterosubtypic antibody cross-reactivity, both between human subtypes and between human and nonhuman subtypes, is common in the human population.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kucharski, Aj" uniqKey="Kucharski A">AJ Kucharski</name></author><author><name sortKey="Gog, Jr" uniqKey="Gog J">JR Gog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paget, J" uniqKey="Paget J">J Paget</name></author><author><name sortKey="Marquet, R" uniqKey="Marquet R">R Marquet</name></author><author><name sortKey="Meijer, A" uniqKey="Meijer A">A Meijer</name></author><author><name sortKey="Van Der Velden, K" uniqKey="Van Der Velden K">K van der Velden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaman, J" uniqKey="Shaman J">J Shaman</name></author><author><name sortKey="Goldstein, E" uniqKey="Goldstein E">E 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uniqKey="Van Der Klis F">FR van der Klis</name></author><author><name sortKey="Ventresca, M" uniqKey="Ventresca M">M Ventresca</name></author><author><name sortKey="Wilks, S" uniqKey="Wilks S">S Wilks</name></author><author><name sortKey="Smith, Dj" uniqKey="Smith D">DJ Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC de Jong</name></author><author><name sortKey="Palache, Am" uniqKey="Palache A">AM Palache</name></author><author><name sortKey="Beyer, We" uniqKey="Beyer W">WE Beyer</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boni, Mf" uniqKey="Boni M">MF Boni</name></author><author><name sortKey="Chau, Nv" uniqKey="Chau N">NV Chau</name></author><author><name sortKey="Dong, N" uniqKey="Dong N">N Dong</name></author><author><name sortKey="Todd, S" uniqKey="Todd S">S Todd</name></author><author><name sortKey="Nhat, Nt" uniqKey="Nhat N">NT Nhat</name></author><author><name sortKey="De Bruin, E" uniqKey="De Bruin E">E de Bruin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gostic, Km" uniqKey="Gostic K">KM Gostic</name></author><author><name sortKey="Ambrose, M" uniqKey="Ambrose M">M Ambrose</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Te Beest, Dennis E" sort="Te Beest, Dennis E" uniqKey="Te Beest D" first="Dennis E." last="Te Beest">Dennis E. Te Beest</name></noRegion><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><name sortKey="Imholz, Sandra" sort="Imholz, Sandra" uniqKey="Imholz S" first="Sandra" last="Imholz">Sandra Imholz</name><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><name sortKey="Te Beest, Dennis E" sort="Te Beest, Dennis E" uniqKey="Te Beest D" first="Dennis E." last="Te Beest">Dennis E. Te Beest</name><name sortKey="Van Boven, Michiel" sort="Van Boven, Michiel" uniqKey="Van Boven M" first="Michiel" last="Van Boven">Michiel Van Boven</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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